The Cosmic Countertop

The Role of Actin Binding Proteins in Uterine and Vulval Muscles in Caenorhabditis elegans

Muscular dystrophy (MD) is a group of muscle diseases that cause the progressive weakness and degeneration of the muscles, affecting approximately 3.6 in 100,000 humans globally. Gene therapy, the manipulation of gene expression to produce a therapeutic effect, is a potential treatment for MD. Actin binding proteins (ABPs) are essential for proper sarcomeric development and structural integrity as they regulate proper actin filament organization which is required for muscle contraction. However, how ABPs behave in a living and developing contractile system remains understudied. Here, I suggest that the development of the uterine and vulval muscles in Caenorhabditis elegans (C. elegans) can be used as an in vivo model to understand muscle development.  In this study, ABPs in C. elegans were depleted using RNA interference (RNAi) to determine their impact on the development and egg-laying abilities of the animals. The impact of ABP depletion can be evaluated by examining phenotypes and determining brood size. Based on several trials, we found that ABPs do play a role in C. elegans development, however the extent of each ABP’s impact varied. Furthermore, our data suggest that some ABPs impact uterine and vulval muscle cell function.

Mentor: Dr. Rebecca Adikes

Research Lab: https://adikeslab.com/

I had an exciting day presenting my science research project at the Greater Capital Region Science and Engineering Fair (GCRSEF) on March 28th 2026. After months of experimentation and analysis, and working with my mentor on “Role of Actin Binding Proteins in the Uerine and Vulval Muscles of Canorhabditis Elegans“, it was a great opportunity and rewarding experience to be selected to present at the fair. 

On the day of the competition, there was a mix of excitement and nerves, but also a great sense of energy in the room. Sharing the space with like-minded students made it even more inspiring—we exchanged ideas, learned from each other, and celebrated our curiosity for science. While presenting to the judges and answering their questions, I learned to communicate my ideas clearly using simple explanations and visuals, while holding my nerves and staying relaxed.

It was truly a wonderful experience, that not only strengthened my confidence and communication skills, but also my passion and curiosity to learn about the unknowns!

When my high school teacher told me I had been selected to present my research at the University at Albany Science Research Invitational Symposium on February 25th 2026, I was beyond thrilled. Presenting at the symposium turned out to be both an exciting and deeply rewarding experience. After dedicating so much time to developing my slides, and working closely with my teacher and mentor, it felt incredibly fulfilling to share my work with others who share the same passion for science.

At the start, I was definitely nervous—especially since I was the first presenter—but as I began speaking, I quickly found my rhythm and grew more confident. I had the opportunity to explain my research, answer thoughtful questions, and receive valuable feedback from the judges. One of the most inspiring aspects of the symposium was seeing the wide range of topics explored by other students. Being surrounded by such motivated peers gave me new perspectives and made the experience even more meaningful. I especially enjoyed discussing ideas and learning about the innovative work others had done.

Although I did not win an award—which was a bit disappointing—the experience itself was incredibly worthwhile. The feedback I received and the chance to observe other presentations taught me a great deal. It motivated me to continue refining both my research and my presentation skills.

Overall, this experience reminded me why I am drawn to science in the first place: curiosity, discovery, and the opportunity to share knowledge with others.